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KMID : 0360220080490101690
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Journal of the Korean Ophthalmological Society
2008 Volume.49 No. 10 p.1690 ~ p.1695
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A Case Report of Intractable Scleritis Effectively Treated with Infliximab
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Kim Dong-Hyun
Wee Won-Ryang
Lee Jin-Hak
Kim Mee-Kum
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Abstract
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Purpose: To report a case of a patient with intractable scleritis with conventional immunosuppressive therapy who showed effective treatment with infliximab.
Case summary: A 71-year-old man presented with orbital cellulitis and diffuse anterior scleritis of his left eye. Although orbital cellulites showed remission with topical and systemic antibiotics, scleritis persisted despite a combination therapy of immunosuppressive agents (cyclosporin, mycophenolate, prednisolone) for 1 month. Finally, he was given infliximab (5 mg/kg) intravenously three times at 2-week intervals, after which ocular pain, chemosis, conjunctival injection, and sclera thickening considerably reduced, and scleritis completely remitted.
Conclusions: The administration of Infliximab seems to be an effective therapy in patients with intractable scleritis undergoing conventional therapy.
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KEYWORD
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Infliximab, Scleritis, TNF-a
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